[Free flap reconstruction after oral and oropharyngeal advanced stage carcinoma surgery].

Autor:	Nao EE; Institut universitaire de la face et du cou, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France. Electronic address: martialnao@yahoo.fr., Dassonville O; Institut universitaire de la face et du cou, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France., Poissonnet G; Institut universitaire de la face et du cou, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France., Santini J; Institut universitaire de la face et du cou, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France., Bozec A; Institut universitaire de la face et du cou, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France.
Jazyk:	francouzština
Zdroj:	Revue de stomatologie, de chirurgie maxillo-faciale et de chirurgie orale [Rev Stomatol Chir Maxillofac Chir Orale] 2014 Apr; Vol. 115 (2), pp. 70-3. Date of Electronic Publication: 2013 Aug 28.
DOI:	10.1016/j.revsto.2013.07.013
Abstrakt:	Introduction: The aim of the study was to evaluate the survival and locoregional recurrence in patients with advanced oral and oropharyngeal squamous cell carcinoma treated by surgery with free flap reconstruction followed or not by radiochemotherapy. Population and Methods: A retrospective study was performed on 188 patients treated by surgery with microvascular reconstruction with or without postoperative radiochemotherapy for an advanced stage squamous carcinoma of the oral cavity and/or of the oropharynx. All patients underwent free flap reconstruction. The study parameters were survival and recurrence rates. Results: The 5-year overall survival, disease specific survival, and disease free survival rates were 54%, 65%, and 61% respectively. A high level of comorbidity was the only factor that influenced the survival rate. The overall recurrence rate was 34%. Only 9% of patients having recurred were treated successfully. The survival rate after locoregional recurrence and metastasis was 6% at 2 years. Discussion: Surgery and postoperative radiochemotherapy allows for an acceptable survival rate for patients with advanced oral and oropharyngeal squamous cell carcinoma. (Copyright © 2013 Elsevier Masson SAS. All rights reserved.)
Databáze:	MEDLINE
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