| Autor: |
Williams RB; Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc. , 1912 Innerbelt Business Center Drive, St. Louis, Missouri 63114, United States., Norman VL, Goering MG, O'Neil-Johnson M, Eldridge GR, Starks CM |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2013 Sep 27; Vol. 76 (9), pp. 1592-7. Date of Electronic Publication: 2013 Aug 26. |
| DOI: |
10.1021/np4002652 |
| Abstrakt: |
The first study of the chemical constituents of Combretum inflatum has resulted in the isolation of seven new acetylated dammarane-type bisdesmosides (1-7). Their structures were determined from microgram quantities on hand using Bruker BioSpin TCI 1.7 mm MicroCryoProbe technology, ESIMS, and comparison to data found in the literature. Compounds 1-7 were screened for inhibition of an Escherichia coli strain UTI89 biofilm, MRSA inhibition, and cytotoxicity in NCI-H460 human lung cancer cells. Compounds 3-7 reduced the growth of MRSA at 16 μg/mL by 71-45%, and compound 7 had an IC₅₀ value of 3.9 μM in NCI-H460. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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