| Autor: |
Iarova EA, Deev AI, Kovaleva NS, Ivkov NN |
| Jazyk: |
ruština |
| Zdroj: |
Farmakologiia i toksikologiia [Farmakol Toksikol] 1978 Jan-Feb; Vol. 41 (1), pp. 8-12. |
| Abstrakt: |
By using a fluorescent 3-metoxybenzatrone probe the binding of the phenothiazine series drugs (chlorpromazine, triftazine, aethaperazine) with phospholipid vesicles--liposomes, was investigated. Cholesterol is shown not to affect the binding of these drugs with liposomes. The surface charge of liposomes influences only the combination with the chlorpromazine membranes. With a higher positive charge of the membranes the binding of chlorpromazine diminishes in force. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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