| Autor: |
Nadkarni DH; Department of Chemistry, University of Alabama at Birmingham, 901 14 Street South, Birmingham, Alabama 35294, USA., Murugesan S, Velu SE |
| Jazyk: |
angličtina |
| Zdroj: |
Tetrahedron [Tetrahedron] 2013 May 20; Vol. 69 (20), pp. 4105-4113. |
| DOI: |
10.1016/j.tet.2013.03.052 |
| Abstrakt: |
Zyzzyanones A-D is a group of biologically active marine alkaloids isolated from Australian marine sponge Zyzzya fuliginosa . They contain a unique bispyrroloquinone ring system as the core structure. The first total synthesis of all four zyzzyanones is described here. The synthesis of these alkaloids started from a previously known 6-benzylamino indole-4,7-quinone derivative and involves 6-7 steps. The key step in the synthesis involves the construction of a pyrrole ring in one step using a Mn(OAc) 3 mediated oxidative free radical cyclization reaction of a 6-benzylamino indole-4,7-quinone derivative with 4-benzyloxyphenyl acetaldehyde diethyl acetal in CH 3 CN. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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