Stress-induced dopamine release in human medial prefrontal cortex--18F-fallypride/PET study in healthy volunteers.

Autor: Nagano-Saito A; Department of Psychiatry, McGill University, Montréal, QC, H3A 1A1, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, H3A 2B4, Canada., Dagher A, Booij L, Gravel P, Welfeld K, Casey KF, Leyton M, Benkelfat C
Jazyk: angličtina
Zdroj: Synapse (New York, N.Y.) [Synapse] 2013 Dec; Vol. 67 (12), pp. 821-30. Date of Electronic Publication: 2013 Sep 12.
DOI: 10.1002/syn.21700
Abstrakt: Background: In laboratory animals, environmental stressors markedly activate the mesocortical dopamine system. The present study tested whether this occurs in humans.
Methods: The effects of a laboratory psychological stressor (Montreal Imaging Stress Task, MIST) on mesocortical dopamine release in healthy young adults (11 males, mean age ± SD, 20.6 ± 2.4 years) was measured using positron emission tomography and [(18)F]fallypride. Each subject was scanned in two separate days in counterbalanced order: one with the MIST and one with the control task. Binding potential (BP ND ) maps of the whole brain were calculated for each scan, using a simplified reference tissue compartmental model. Then BP ND was compared between subjects. Heart rate, galvanic skin response, and salivary cortisol level were measured during the scans.
Results: The psychological stressor significantly decreased [(18)F]fallypride binding values in the dorsal part of the medial prefrontal cortex (dmPFC), corresponding to the rostal part of the cingulate motor zone. The greater the stress-induced decrease in [(18)F]fallypride binding in the dmPFC, the greater the stress-induced increases in heart rate.
Conclusions: The present study provides evidence of stress-induced dopamine release in the mPFC in humans, in vivo.
(Copyright © 2013 Wiley Periodicals, Inc.)
Databáze: MEDLINE
Externí odkaz: