Stress-induced dopamine release in human medial prefrontal cortex--18F-fallypride/PET study in healthy volunteers.
Autor: | Nagano-Saito A; Department of Psychiatry, McGill University, Montréal, QC, H3A 1A1, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, H3A 2B4, Canada., Dagher A, Booij L, Gravel P, Welfeld K, Casey KF, Leyton M, Benkelfat C |
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Jazyk: | angličtina |
Zdroj: | Synapse (New York, N.Y.) [Synapse] 2013 Dec; Vol. 67 (12), pp. 821-30. Date of Electronic Publication: 2013 Sep 12. |
DOI: | 10.1002/syn.21700 |
Abstrakt: | Background: In laboratory animals, environmental stressors markedly activate the mesocortical dopamine system. The present study tested whether this occurs in humans. Methods: The effects of a laboratory psychological stressor (Montreal Imaging Stress Task, MIST) on mesocortical dopamine release in healthy young adults (11 males, mean age ± SD, 20.6 ± 2.4 years) was measured using positron emission tomography and [(18)F]fallypride. Each subject was scanned in two separate days in counterbalanced order: one with the MIST and one with the control task. Binding potential (BP ND ) maps of the whole brain were calculated for each scan, using a simplified reference tissue compartmental model. Then BP ND was compared between subjects. Heart rate, galvanic skin response, and salivary cortisol level were measured during the scans. Results: The psychological stressor significantly decreased [(18)F]fallypride binding values in the dorsal part of the medial prefrontal cortex (dmPFC), corresponding to the rostal part of the cingulate motor zone. The greater the stress-induced decrease in [(18)F]fallypride binding in the dmPFC, the greater the stress-induced increases in heart rate. Conclusions: The present study provides evidence of stress-induced dopamine release in the mPFC in humans, in vivo. (Copyright © 2013 Wiley Periodicals, Inc.) |
Databáze: | MEDLINE |
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