| Autor: |
Curnutte JT, Kipnes RS, Babior BM |
| Jazyk: |
angličtina |
| Zdroj: |
The New England journal of medicine [N Engl J Med] 1975 Sep 25; Vol. 293 (13), pp. 628-32. |
| DOI: |
10.1056/NEJM197509252931303 |
| Abstrakt: |
Particulate fractions from normal human granulocytes preactivated with opsonized zymosan were found to catalyze superoxide production in the presence of reduced pyridine nucleotides. Similar preparations from three patients with X-linked chronic granulomatous disease produced no detectable superoxide. The failure to produce superoxide was not due to an inhibitor, since cell-free preparations from the patients' granulocytes had no effect on superoxide production by normal particles. Particles from the mothers of two of the patients produced superoxide at diminished rates; superoxide production by particles from the third mother was normal. These findings suggest that chronic granulomatous disease represents either a defect in a pyridine nucleotide-dependent superoxide-forming oxidase or a lesion in the apparatus responsible for activating the oxidase. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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