Seizures from valproate-carbapenem interaction.

Autor: Taha FA; Division of Pediatric Neurology, Nemour's Children's Clinic, and the Department of Neurology, Mayo Clinic, Jacksonville, Florida., Hammond DN, Sheth RD
Jazyk: angličtina
Zdroj: Pediatric neurology [Pediatr Neurol] 2013 Oct; Vol. 49 (4), pp. 279-81. Date of Electronic Publication: 2013 Aug 06.
DOI: 10.1016/j.pediatrneurol.2013.03.022
Abstrakt: Background: Antiepileptic medication interactions can complicate the management of epilepsy, by either increasing or reducing the effective serum concentrations thereby causing adverse effects or loss of seizure control.
Results: A 14-year-old girl with well-controlled juvenile absence epilepsy lost control of her seizures acutely following the administration of carbapenem for pneumonia. Serum valproate concentrations fell by 90% within 48 hours following carbapenem and returned to baseline following its discontinuation.
Conclusions: Awareness of this clinically significant interaction alters clinical practice by avoiding carbapenem or temporary use of adjunctive medication to prevent the clinical consequences of this significant drug interaction.
(Copyright © 2013 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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