Bioactive stilbenes from Vitis vinifera grapevine shoots extracts.

Autor: Chaher N; Université de Bejaia, Faculté des Sciences de la Nature et de la vie, Laboratoire de Biochimie Appliquée, Bejaia, 06000, Algérie., Arraki K, Dillinseger E, Temsamani H, Bernillon S, Pedrot E, Delaunay JC, Mérillon JM, Monti JP, Izard JC, Atmani D, Richard T
Jazyk: angličtina
Zdroj: Journal of the science of food and agriculture [J Sci Food Agric] 2014 Mar 30; Vol. 94 (5), pp. 951-4. Date of Electronic Publication: 2013 Sep 04.
DOI: 10.1002/jsfa.6341
Abstrakt: Background: Viticultural residues from commercial viticultural activities represent a potentially important source of bioactive stilbenes such as resveratrol. The main aim of the present study was therefore to isolate, identify and perform biological assays against amyloid-β peptide aggregation of original stilbenes from Vitis vinifera shoots.
Results: A new resveratrol oligomer, (Z)-cis-miyabenol C (3), was isolated from Vitis vinifera grapevine shoots together with two newly reported oligostilbenes from Vitis vinifera shoots, vitisinol C (1) and (E)-cis-miyabenol C (2), and six known compounds: piceatannol, resveratrol, (E)-ε-viniferin (trans-ε-viniferin), ω-viniferin, vitisinol C and (E)-miyabenol C. The structures of these resveratrol derivatives were established on the basis of detailed spectroscopic analysis including nuclear magnetic resonance experiments. All the newly reported compounds were tested for their anti-aggregative activity against amyloid-β fibril formation. Vitisinol C was found to exert a significant activity against amyloid-β aggregation.
Conclusion: Vitis vinifera grapevine shoots are potentially interesting as a source of new bioactive stilbenes, such as vitisinol C.
(© 2013 Society of Chemical Industry.)
Databáze: MEDLINE
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