| Autor: |
Ysebrant de Lendonck L; Institute for Medical Immunology (IMI), Université Libre de Bruxelles, Charleroi, Belgium., Eddahri F, Delmarcelle Y, Nguyen M, Leo O, Goriely S, Marchant A |
| Jazyk: |
angličtina |
| Zdroj: |
PloS one [PLoS One] 2013 Jul 26; Vol. 8 (7), pp. e71029. Date of Electronic Publication: 2013 Jul 26 (Print Publication: 2013). |
| DOI: |
10.1371/journal.pone.0071029 |
| Abstrakt: |
The generation of high-affinity antibodies and the development of B cell memory are dependent on the help provided by CD4 T cells. Mouse studies indicate that STAT3 signaling in CD4 T cells promotes the acquisition of the B cell help function. However, the role of STAT3 in humans has been controversial. In this study, we show that IL-6 and other STAT3 activating cytokines (IL-21 and IL-27) induce the differentiation of CD4 T cells promoting antibody production by B cells. The acquisition of B cell stimulating properties by naive cord blood CD4 T cells required the STAT3-dependent expression of ICOS and IL-21. Gene reporter and ChIP experiments unambiguously demonstrated that upon IL-6 stimulation, STAT3 induces the transcription of the ICOS gene through direct recruitment to the proximal promoter region indicating that STAT3 acts in part through the direct activation of the ICOS gene. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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