Advanced glycation endproducts in children with diabetes.

Autor: Shah S; Division of Pediatric Endocrinology/Diabetes, Louisiana State University-Health Sciences Center and Children's Hospital, New Orleans, LA., Baez EA, Felipe DL, Maynard JD, Hempe JM, Chalew SA
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2013 Nov; Vol. 163 (5), pp. 1427-31. Date of Electronic Publication: 2013 Aug 03.
DOI: 10.1016/j.jpeds.2013.06.044
Abstrakt: Objectives: To estimate skin content of advanced glycation endproducts (AGEs) by measurements of skin intrinsic fluorescence (SIF) from youth with diabetes in comparison with a population of youth and adults without diabetes.
Study Design: Using a specialized instrument, skin AGEs were estimated from skin auto-fluorescence induced at 420 nm and corrected for skin pigmentation (SIF420[kx0.5, km0.5]) in children with types 1 and 2 diabetes, as well as children and adults without diabetes. The effect of age, sex, ethnicity, and diabetes status on SIF420[kx0.5, km0.5] was analyzed.
Results: SIF420[kx0.5, km0.5] increased with chronologic age and was higher in children with diabetes compared with children without diabetes (P = .0001). SIF420[kx0.5, km0.5] from 43% of children with type 1 diabetes and 55% with type 2 diabetes overlapped the range of adults without diabetes. SIF420[kx0.5, km0.5] was higher in girls than boys in patients with diabetes patients. However, there was no effect of sex or race on SIF420[kx0.5, km0.5] in subjects without diabetes.
Conclusions: After 4-6 years' exposure to diabetes, many children will have precociously high estimates of skin AGEs, comparable with levels that would naturally accumulate only after ∼25 years of chronologic aging. Potentially, this technology identifies children who are at increased risk for complications.
(Copyright © 2013 Mosby, Inc. All rights reserved.)
Databáze: MEDLINE
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