Experience with low-dose rituximab in off-label indications at two tertiary hospitals.

Autor: Chay J; Department of Rheumatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia. jackychay@hotmail.com, Donovan P, Cummins L, Kubler P, Pillans P
Jazyk: angličtina
Zdroj: Internal medicine journal [Intern Med J] 2013 Aug; Vol. 43 (8), pp. 871-82.
DOI: 10.1111/imj.12207
Abstrakt: Background: Rituximab is a monoclonal antibody directed against B cells and is increasingly used to treat a variety of autoimmune conditions. Most published evidence reporting the successful use of rituximab in off-label indications has empirically used a high-dose regimen (either 375 mg/m(2) weekly for 4 weeks, or 1000 mg × 2), which is the approved course of treatment for lymphoma and rheumatoid arthritis patients.
Aims: The aims of this report are to review the indications, outcomes and adverse events of low-dose (500 mg twice, given 1-2 weeks apart), off-label use of rituximab in our institutions, and to review the available evidence.
Methods: We performed a retrospective audit of the off-label use of low-dose rituximab at two university teaching, tertiary referral hospitals, from mid-2008 until the end of 2011.
Results: Off-label rituximab was given to 52 patients (53 indications) across a heterogeneous group of autoimmune conditions. Outcomes were known for 46 conditions (affecting 45 patients), and of these, complete responses were observed in 16 (35%) conditions and a further 19 (41%) had a partial response. There was no response to rituximab in 11 (24%) patients. There were eight significant adverse events, mostly related to infectious complications.
Conclusion: This case series suggests that low-dose courses of rituximab can be used off-label to treat several severe and/or refractory immunological disorders with a reasonable safety profile; however, further trials are required in many off-label indications.
(© 2013 The Authors; Internal Medicine Journal © 2013 Royal Australasian College of Physicians.)
Databáze: MEDLINE
Externí odkaz: