The effects of mechanical ventilation on oxidative stress.

Autor:	Mazullo Filho JB, Bona S, Rosa DP, Silva FG, Forgiarini Junior LA, Dias AS, Marroni NP
Jazyk:	English; Portuguese
Zdroj:	Revista Brasileira de terapia intensiva [Rev Bras Ter Intensiva] 2012 Mar; Vol. 24 (1), pp. 23-9.
Abstrakt:	Objective: Mechanical ventilation is a mainstay of therapy in intensive care units; however, its deleterious effects need to be assessed. Therefore, we aimed to assess oxidative stress in patients admitted to an intensive care unit undergoing invasive mechanical ventilation. Methods: This cross-sectional study included 12 invasive mechanical ventilation patients. Blood samples (3 mL) were collected on the first and last days on invasive mechanical ventilation. Thiobarbituric acid-reacting substances (TBARS) were assessed in plasma, and superoxide dismutase (SOD) and catalase (CAT) were assessed in erythrocytes. Results: The mean age was 64.8 ± 17.6 years, the tidal volume (VT) 382 ± 44.5 mL, and the APACHE II score 15 ± 7. When initial and final TBARS were compared, a significant difference was identified (3.54 ± 0.74 vs. 4.96 ± 1.47, p = 0.04). Antioxidant enzymes showed no significant differences. Correlations between PaO2/FiO2 and TBARS (r = 0.4), SOD and PaO2/FiO2 (r = 0.51) and APACHE II and SOD (r = 0.56) were identified. Six patients died. Conclusion: Patients undergoing invasive mechanical ventilation can develop redox state changes, showing increased TBARS and reduced antioxidant enzymes.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu