18F-FDG PET and PET/CT in the Localization and Characterization of Lesions in Patients with Ovarian Cancer.
| Autor: | Caprio MG; Azienda Ospedaliera Universitaria Federico II, Napoli, Italia., Capacchione D, Mainolfi C, Spera AM, Salvatore B, Cella L, Salvatore M, Pace L |
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| Jazyk: | angličtina |
| Zdroj: | Translational medicine @ UniSa [Transl Med UniSa] 2012 Jan 18; Vol. 2, pp. 28-35. Date of Electronic Publication: 2012 Jan 18 (Print Publication: 2012). |
| Abstrakt: | Aim: The aim was to compare the imaging findings of (18)F-fluorodeoxyglucose ((18)F-FDG) PET and integrated PET/CT in patients with primary, recurrent or metastatic ovarian cancer. Materials and Methods: 21 women with ovarian cancer were evaluated. All patients had a integrated PET/CT scan. Localization, infiltration and uptake intensity of [(18)F]FDG were evaluated on PET and PET/CT. The certainty of localisation and characterisation was scored on a 3 point scale (L1 definite localisation; L2 probable localisation; L3 uncertain localisation; C1 benign; C2 equivocal; C3 malignant). Results: PET scored as L1 54 lesions (44%), as L2 51 (42%), and as L3 17 (14%). On the other hand, PET/CT scored as L1 120 lesions (98%), as L2 2 (2%), and none as L3. Thus PET/CT allowed a better localization in 54% of lesions. Moreover, PET scored as C1 25 lesions (20%), as C2 62 (51%), and as C3 35 (29%). On the other hand, PET/CT scored as C1 57 lesions (47%), as C2 13 (11%), and as C3 52 (42%). Thus PET/CT allowed a sensible reduction in the number of equivocal lesions (40%). Even when patients were subgrouped on the basis of clinical stage of the disease, PET/CT was capable of better definition of the lesions either for localization and for characterization. Conclusions: In patients with ovarian cancer, PET/CT allows better anatomical localisation of pathologic uptake providing high accuracy for staging and restaging of ovarian cancer when compared with PET alone. |
| Databáze: | MEDLINE |
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