Non-cytotoxic dimedone derivatives: structure, antiradical and UV protective studies.
| Autor: | Joshi PV; Centre for Materials Characterization, National Chemical Laboratory, Pune, India., Mundhe KS; Dr. T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parashurambhau College, Pune, India., Khan AA; Institute of Bioinformatics & Biotechnology, University of Pune, Pune, India., Gawade RL; Centre for Materials Characterization, National Chemical Laboratory, Pune, India., Deshpande NR; Dr. T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parashurambhau College, Pune, India., Kashalkar RV; Dr. T. R. Ingle Research Laboratory, Department of Chemistry, Sir Parashurambhau College, Pune, India., Puranik VG; Centre for Materials Characterization, National Chemical Laboratory, Pune, India. |
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| Jazyk: | angličtina |
| Zdroj: | Drug research [Drug Res (Stuttg)] 2013 Dec; Vol. 63 (12), pp. 650-6. Date of Electronic Publication: 2013 Jul 31. |
| DOI: | 10.1055/s-0033-1351287 |
| Abstrakt: | Dimedone derivatives (L1-L4) with methyl substitution at the ortho, para and meta positions were synthesized and their anti-radical, photoreactive and photostability activities were evaluated. All compounds are characterized by spectroscopic techniques and by single crystal X ray diffraction. UV exposure experiments on pBR322 showed inhibition of plasmid DNA fragmentation by UV radiation in a dose dependent manner. Radical scavenging assays and ESR spectra indicate that these compounds possess antiradical activities and do not photodegrade to form other side products as confirmed by chromatographic analysis. They are non-cytotoxic towards human keratinocyte HaCaT cell line indicates their potentiality in sunscreens. (© Georg Thieme Verlag KG Stuttgart · New York.) |
| Databáze: | MEDLINE |
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