Hyalinizing clear cell carcinoma of the parotid gland: report of a recurrent case with aggressive cytomorphology and behavior diagnosed on fine-needle cytology sample.

Autor: Fulciniti F; S.S.D. di Citopatologia, S.C. di Anatomia Patologica e Citopatologia, Naples, Italy., Pia Curcio M, Liguori G, Aquino G, Botti G, Campanile AC, De Cecio R, Pavone E, Aversa C, Perri F, Caponigro F, Ionna F
Jazyk: angličtina
Zdroj: Diagnostic cytopathology [Diagn Cytopathol] 2014 Jan; Vol. 42 (1), pp. 63-8. Date of Electronic Publication: 2013 Jul 27.
DOI: 10.1002/dc.22956
Abstrakt: A case of recurrent hyalinizing clear cell carcinoma (HCCC) of the parotid gland in a 46-year-old female is here introduced. The patient had undergone a left superficial parotidectomy 6 months ago in another institution for an alleged benign, circumscribed mass 2.4 cm in diameter of the left parotid gland. Histopathological examination revealed a poorly differentiated HCCC bearing a EWSR-1 translocation on FISH examination. Fine Needle Cytology (FNC) was performed on three separate soft tissue masses in the pre-masseterine area and a cytological diagnosis of recurrent, poorly differentiated, possibly aggressive variant of HCCC, was rendered. FISH performed on a destained Diff Quik stained smear demonstrated an ESWR-1 translocation, which supported the cytopathological diagnosis. The cytomorphologic features and the differential diagnosis of this aggressive variant of HCCC are briefly discussed.
(Copyright © 2013 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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