Association between serum fetuin-A levels, carotid artery stiffness, and intima-media thickness in patients with normotensive obstructive sleep apnea syndrome.

Autor:	Akyuz A; Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey ayakyuzq5@gmail.com., Oran M; Department of Internal Medicine, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey., Alpsoy S; Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey., Mutlu LC; Department of Chest Disease, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey., Akkoyun DC; Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey., Guzel S; Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey., Alp R; Department of Neurology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey.
Jazyk:	angličtina
Zdroj:	Angiology [Angiology] 2014 Aug; Vol. 65 (7), pp. 607-13. Date of Electronic Publication: 2013 Jul 26.
DOI:	10.1177/0003319713497421
Abstrakt:	Increased carotid intima-media thickness (cIMT) and stiffness, reflecting subclinical atherosclerosis, are associated with obstructive sleep apnea syndrome (OSAS). The relationship between serum fetuin-A, which inhibits ectopic calcification, and atherosclerosis is unclear. Therefore, we investigated the association between serum fetuin-A levels and carotid artery stiffness and cIMT in patients with normotensive OSAS (n = 50) and non-OSAS controls (n = 38). Compared with controls, there were lower fetuin-A levels (59.4 ± 6.5 vs 68.2 ± 5.8 ng/mL, P = .029), higher mean cIMT (0.73 ± 0.2 vs 0.63 ± 0.3 mm, P < .001), and greater stiffness (β) index (7.45 ± 0.9 vs 5.2 ± 0.7, P = .001) in the OSAS group. The cIMT and stiffness (β) index were inversely correlated with fetuin-A levels (r = -.324, P = .033; r = -.466, P < .001, respectively) and positively correlated with apnea hypopnea index (r = .498, P < .001; r = .422, P = .001, respectively) in the OSAS group. Decreased serum fetuin-A levels were associated with subclinical carotid atherosclerosis in patients with normotensive OSAS. (© The Author(s) 2013.)
Databáze:	MEDLINE
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