| Autor: |
Fonseca-Silva F; Laboratório de Bioquímica de Tripanosomatideos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Pavilhão Leônidas Deane, Manguinhos, 21045-900 Rio de Janeiro, Rio de Janeiro, Brazil., Inacio JD, Canto-Cavalheiro MM, Almeida-Amaral EE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2013 Aug 23; Vol. 76 (8), pp. 1505-8. Date of Electronic Publication: 2013 Jul 22. |
| DOI: |
10.1021/np400193m |
| Abstrakt: |
The present study reports the mechanism of the antileishmanial activity of quercetin against the intracellular amastigote form of Leishmania amazonensis. Treatment with 1 reduced the infection index in L. amazonensis-infected macrophages in a dose-dependent manner, with an IC₅₀ value of 3.4 μM and a selectivity index of 16.8, and additionally increased ROS generation also in a dose-dependent manner. Quercetin has been described as a pro-oxidant that induces the production of reactive oxygen species, which can cause cell death. Taken together, these results suggest that ROS production plays a role in the mechanism of action of 1 in the control of intracellular amastigotes of L. amazonensis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
