| Autor: |
Gritsenko AN, Lyskovtsev VV, Senova ZP, Skoldinov AP, Stark A, Wunderlich G, Poppe H, Barch R |
| Jazyk: |
ruština |
| Zdroj: |
Farmakologiia i toksikologiia [Farmakol Toksikol] 1990 May-Jun; Vol. 53 (3), pp. 30-2. |
| Abstrakt: |
The antiarrhythmic activity of 20 derivatives of dibenzazepine (the effects on the maximal effective rabbit heart auricle contraction rate, aconitine-induced arrhythmia in rats under or without anesthesia) was studied. It was shown that the most active compounds are those with carbethoxyamine group in position 3 in combination with dimethylamino- or diethylamino-acetyl groups in position 5 of dibenzazepine ring. 5-dimethyl-aminoacetyl-10,11-dihydro-5H-dibenz b, f azepine (GS-015, bonnecor) was selected for the further detailed investigation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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