Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series.

Autor: Ramachandran S; Department of Medicinal Chemistry, AstraZeneca India Pvt Ltd, Avishkar, Bellary Road, Hebbal, Bangalore 560024, India. sreekanth.ramachandran@astrazeneca.com, Panda M, Mukherjee K, Choudhury NR, Tantry SJ, Kedari CK, Ramachandran V, Sharma S, Ramya VK, Guptha S, Sambandamurthy VK
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Sep 01; Vol. 23 (17), pp. 4996-5001. Date of Electronic Publication: 2013 Jun 24.
DOI: 10.1016/j.bmcl.2013.06.043
Abstrakt: Imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead were generated by whole cell screening of a focused library against Mycobacterium tuberculosis. Herein, we describe the synthesis and structure activity relationship evaluation of this class of inhibitors and the optimization of physicochemical properties. These are selective inhibitors of Mycobacterium tuberculosis with no activity on either gram positive or gram negative pathogens.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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