Toll-deficient Drosophila is susceptible to Pythium insidiosum infection.

Autor: Zanette RA; Graduate Program in Pharmacology, Federal University of Santa Maria, Avenida Roraima, 1000, Santa Maria, RS, 97105-900, Brazil; Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA., Santurio JM, Loreto ÉS, Alves SH, Kontoyiannis DP
Jazyk: angličtina
Zdroj: Microbiology and immunology [Microbiol Immunol] 2013 Oct; Vol. 57 (10), pp. 732-5.
DOI: 10.1111/1348-0421.12082
Abstrakt: There is a paucity of animal models of pythiosis, a life-threatening disease of humans and animals, the immunopathogenesis of which is poorly understood. A pythiosis model was developed by injecting Toll (Tl)-deficient Drosophila melanogaster flies with Pythium insidiosum zoospores. The infected Tl mutant flies had significantly lower survival rates (73.7%) than did control flies. This study reveals the important role of Tl pathway activation in fly immune response to pythiosis.
(© 2013 The Societies and Wiley Publishing Asia Pty Ltd.)
Databáze: MEDLINE
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