How to understand the association between cystatin C levels and cardiovascular disease: Imbalance, counterbalance, or consequence?

Autor: Salgado JV; Kidney Disease Prevention Centre, Clinical Chemistry Service, Federal University of Maranhão, Brazil. Electronic address: jvlsalgado@yahoo.com.br., Souza FL; Kidney Disease Prevention Centre, Cardiology Service, Federal University of Maranhão, Brazil., Salgado BJ; Department of Endocrinology and Metabolism, Federal University of Maranhão, Brazil.
Jazyk: angličtina
Zdroj: Journal of cardiology [J Cardiol] 2013 Dec; Vol. 62 (6), pp. 331-5. Date of Electronic Publication: 2013 Jul 09.
DOI: 10.1016/j.jjcc.2013.05.015
Abstrakt: The association of cystatin C with renal function has been studied for more than 25 years. Cystatin C has been described to have a better diagnostic performance than creatinine to assess renal function, particularly to detect small reductions in glomerular filtration rate. Recently, cystatin C has emerged as a strong predictor of incident or recurrent cardiovascular events and adverse outcomes in patients without kidney disease. Furthermore, it has been suggested that cystatin C concentrations are directly related to both inflammation and atherosclerosis. Nevertheless, the link between inflammation, atherogenesis, cardiovascular risk, and cystatin C is still poorly understood. This brief report discusses recent data, contrasting findings and possible mechanisms involved in this interaction.
(Copyright © 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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