Measurements of tumor vascular leakiness using DCE in brain tumors: clinical applications.

Autor: Jain R; Department of Radiology, Division of Neuroradiology, Henry Ford Health System, Detroit, MI 48202, USA. rajanj@rad.hfh.edu
Jazyk: angličtina
Zdroj: NMR in biomedicine [NMR Biomed] 2013 Aug; Vol. 26 (8), pp. 1042-9. Date of Electronic Publication: 2013 Jul 07.
DOI: 10.1002/nbm.2994
Abstrakt: Various imaging techniques have been employed to evaluate blood-brain-barrier leakiness in brain tumors, as higher tumor vascular leakiness is known to be associated with higher grade and malignant potential of the tumor, and hence can help provide additional diagnostic and prognostic information. These imaging techniques range from routine post-contrast T1 -weighted images that highlight degree of contrast enhancement to absolute measurement of quantitative metrics of vascular leakiness employing complex pharmacokinetic modeling. The purpose of this article is to discuss the clinical applications of available imaging techniques, and in particular dynamic contrast-enhanced T1 -weighted MR imaging (DCE-MRI), to evaluate tumor vascular leakiness.
(Copyright © 2013 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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