Brain cortical thickness in the general elderly population: the Rotterdam Scan Study.

Autor: van Velsen EF; Department of Epidemiology, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands., Vernooij MW, Vrooman HA, van der Lugt A, Breteler MM, Hofman A, Niessen WJ, Ikram MA
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2013 Aug 29; Vol. 550, pp. 189-94. Date of Electronic Publication: 2013 Jul 03.
DOI: 10.1016/j.neulet.2013.06.063
Abstrakt: Cortical thickness is considered a potentially relevant marker for neurodegenerative diseases. However, the relationship of demographic and vascular risk factors with cortical thickness remains unclear. In a population-based sample of 1022 non-demented elderly persons (mean age 68.4±7.3 years), we examined aging effects on global and lobar cortical thickness and the relationship with demographic variables and cardiovascular risk factors. We used a validated model-based approach to calculate mean cortical thickness (μm) in brain MR-images. We found that women had a significant thicker cortex than men (p<0.01). Further, with increasing age, cortical thickness decreased (approximately 0.2% per year), with the largest age effects for the occipital and temporal lobes, and the decrease in the frontal lobe being more apparent in men than in women (p-interaction<0.001). Additionally, higher education, higher diastolic blood pressure and larger intra-cranial volume were related to a larger cortical thickness, whilst diabetes mellitus and higher HDL cholesterol levels were related to a thinner cortex.
(Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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