Clinical pregnancy after uterus transplantation.
| Autor: | Erman Akar M; Department of Obstetrics and Gynecology, Akdeniz University, Antalya, Turkey. Electronic address: meakar@akdeniz.edu.tr., Ozkan O, Aydinuraz B, Dirican K, Cincik M, Mendilcioglu I, Simsek M, Gunseren F, Kocak H, Ciftcioglu A, Gecici O, Ozkan O |
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| Jazyk: | angličtina |
| Zdroj: | Fertility and sterility [Fertil Steril] 2013 Nov; Vol. 100 (5), pp. 1358-63. Date of Electronic Publication: 2013 Jul 03. |
| DOI: | 10.1016/j.fertnstert.2013.06.027 |
| Abstrakt: | Objective: To present the first clinical pregnancy after uterus transplantation. Design: Case study. Setting: Tertiary center. Patient(s): A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation. Intervention(s): Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos. Main Outcome Measure(s): Implantation of embryo in an allografted human uterus. Result(s): The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization. Conclusion(s): We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works. (Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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