Effects of simvastatin in prevention of pain recurrences after surgery for endometriosis.
| Autor: | Almassinokiani F; Minimally Invasive Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran. dralmassi@yahoo.com, Mehdizadeh A, Sariri E, Rezaei M, Almasi A, Akbari H, Pazooki A, Solaymani-Dodaran M, Asadollah S, Amirkhani J, Chaichian S, Vahdat M, Moosavi A, Ashouri M, Tamannaei Z |
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| Jazyk: | angličtina |
| Zdroj: | Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2013 Jul 05; Vol. 19, pp. 534-9. Date of Electronic Publication: 2013 Jul 05. |
| DOI: | 10.12659/MSM.883967 |
| Abstrakt: | Background: To compare efficacy of simvastatin with GnRHa (Decapeptyl 3.75 mg) on endometriosis-related pains following surgery for endometriosis. Material/methods: Sixty women with pelvic endometriosis, after laparoscopic diagnosis and conservative laparoscopic surgery, were treated with either simvastatin (n=30) for 16 weeks or Decapeptyl (n=30) every 4 weeks for 4 doses. Results: Using VAS, the score of dyspareunia, dysmenorrhea, and pelvic pain 6 months after laparoscopic surgery declined significantly in both groups (p=0.001), but the difference between results of the 2 groups was not significant (p>0.05). Conclusions: Both treatment modalities showed comparable effectiveness in the treatment of pains related to endometriosis. |
| Databáze: | MEDLINE |
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