| Autor: |
Harrison OJ; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom., Powrie FM |
| Jazyk: |
angličtina |
| Zdroj: |
Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2013 Jul 01; Vol. 5 (7). Date of Electronic Publication: 2013 Jul 01. |
| DOI: |
10.1101/cshperspect.a018341 |
| Abstrakt: |
A fundamental role of the mammalian immune system is to eradicate pathogens while minimizing immunopathology. Instigating and maintaining immunological tolerance within the intestine represents a unique challenge to the mucosal immune system. Regulatory T cells are critical for continued immune tolerance in the intestine through active control of innate and adaptive immune responses. Dynamic adaptation of regulatory T-cell populations to the intestinal tissue microenvironment is key in this process. Here, we discuss specialization of regulatory T-cell responses in the intestine, and how a breakdown in these processes can lead to chronic intestinal inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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