Influenza virus A(H3N2) strain isolated from cerebrospinal fluid from a patient presenting myelopathy post infectious.

Autor: Paiva TM; Núcleo de Doenças Respiratórias, Instituto Adolfo Lutz, São Paulo, SP, Brazil. tterezinha@uol.com.br, Theotonio G, Paulino RS, Benega MA, Silva DB, Borborema SE, Ikeda TI, Kisielius JJ, Ueda M, Oliveira MI, Santos CL
Jazyk: angličtina
Zdroj: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [J Clin Virol] 2013 Sep; Vol. 58 (1), pp. 283-5. Date of Electronic Publication: 2013 Jun 25.
DOI: 10.1016/j.jcv.2013.05.021
Abstrakt: Background: Neurological involvement during influenza infection has been described during epidemics and is often consistent with serious sequelae or death.
Objective: To investigate the etiologic agent involved in myelopathy post influenza-like syndrome.
Study Design: This investigation focuses on virus isolation from the cerebrospinal fluid (CSF) collected from a 19-year-old male student presenting with clinical diagnosis of myelopathy post influenza-like syndrome. To achieve this goal, different cell cultures and molecular methodologies were carried out.
Results: Influenza virus A(H3N2) strain was isolated in MDCK cell culture; virus particles were observed under electron microscopy. Phylogenetics analyses showed that the Brazilian influenza A(H3N2) strains were closely related to the A/Perth/16/2009-like.
Conclusion: This study demonstrates that influenza virus A(H3N2) strain was the cause of illness of the students. According to the Brazilian influenza virus sentinel surveillance data A/Perth/16/2009-LIKE (H3N2) strain has predominated during the 2010 influenza virus season in Brasília-DF.
(Copyright © 2013 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: