Clinical implications of current developments in genitourinary pathology.
| Autor: | Zhou AG; Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01605, USA., Owens CL, Cosar EF, Jiang Z |
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| Jazyk: | angličtina |
| Zdroj: | Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2013 Jul; Vol. 137 (7), pp. 887-93. |
| DOI: | 10.5858/arpa.2012-0210-RA |
| Abstrakt: | Context: Several developments in genitourinary pathology are likely to change our understanding and management of some genitourinary cancers considerably. Objective: To review 5 stories in genitourinary pathology: (1) fusion in the ETS (E26) gene family in prostatic adenocarcinoma; (2) insulin-like growth factor II messenger RNA-binding protein 3 (IMP3), an important prognostic biomarker for kidney and bladder cancers; (3) translocation renal cell carcinoma; (4) UroVysion fluorescence in situ hybridization test in urine cytology for detection of bladder cancer; and (5) the use of triple immunostaining for diagnosis of prostate cancer. Data Sources: Literature review and authors' personal experiences. Conclusions: Many scientific findings have contributed recently to the understanding of the natural pathogenesis and progression of genitourinary cancers. This translational research helps in diagnosing, predicting, and potentially, treating genitourinary cancers. |
| Databáze: | MEDLINE |
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