| Autor: |
Guinebault P; Synthélabo-Recherche (L.E.R.S.), Meudon-la-Fôret, France., Colafranceschi C, Bianchetti G |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of chromatography [J Chromatogr] 1990 May 16; Vol. 507, pp. 221-5. |
| DOI: |
10.1016/s0021-9673(01)84197-2 |
| Abstrakt: |
A procedure for the determination of the CNS-active muscle-relaxant mephenesin in plasma samples is described. The method involved a single-step extraction with diethyl ether followed by high-performance liquid chromatography separation and fluorimetric detection. Linearity of the detection response was observed between 1 ng/ml, which is the limit of determination, and 500 ng/ml. Inter-day assays, including quality-control samples, performed over a 4-month period, showed the method to be reproducible and precise, and suitable for routine analysis in pharmacokinetic studies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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