Daptomycin In Vitro Activity against Methicillin-Resistant Staphylococcus aureus Is Enhanced by d-Cycloserine in a Mechanism Associated with a Decrease in Cell Surface Charge.

Autor:	Gasch O; Beth Israel Deaconess Medical Center ogasch@bellvitgehospital.cat.; Harvard Medical School, Boston, Massachusetts, USA.; Hospital Universitari de Bellvitge, Barcelona, Spain., Pillai SK; Beth Israel Deaconess Medical Center.; Harvard Medical School, Boston, Massachusetts, USA., Dakos J; Beth Israel Deaconess Medical Center., Miyakis S; Beth Israel Deaconess Medical Center.; Harvard Medical School, Boston, Massachusetts, USA.; Graduate School of Medicine, University of Wollongong, New South Wales, Australia., Moellering RC Jr; Beth Israel Deaconess Medical Center.; Harvard Medical School, Boston, Massachusetts, USA., Eliopoulos GM; Beth Israel Deaconess Medical Center.; Harvard Medical School, Boston, Massachusetts, USA.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Sep; Vol. 57 (9), pp. 4537-4539. Date of Electronic Publication: 2013 Jun 24.
DOI:	10.1128/AAC.00799-13
Abstrakt:	The killing activity of daptomycin against an isogenic pair of daptomycin-susceptible and daptomycin-nonsusceptible (DNS) methicillin-resistant Staphylococcus aureus (MRSA) strains was enhanced by the addition of certain cell wall agents at 1× MIC. However, when high inocula of the DNS strain were used, no significant killing was observed in our experiments. Cytochrome c binding assays revealed d-cycloserine as the only agent associated with a reduction in the cell surface charge for both strains at the concentrations used. (Copyright © 2013, American Society for Microbiology. All Rights Reserved.)
Databáze:	MEDLINE
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