TRAIL mRNA expression in peripheral blood mononuclear cells of Egyptian SLE patients.

Autor: El-Karaksy SM; Department of Clinical Pathology, Kasr El Aini Hospital, Cairo University, Cairo, Egypt., Kholoussi NM, Shahin RM, El-Ghar MM, Gheith Rel-S
Jazyk: angličtina
Zdroj: Gene [Gene] 2013 Sep 15; Vol. 527 (1), pp. 211-4. Date of Electronic Publication: 2013 Jun 18.
DOI: 10.1016/j.gene.2013.05.084
Abstrakt: Although the definite etiopathogenesis of systemic lupus erythematosus (SLE) remains unclear, many different mechanisms may contribute to its pathogenesis. Tumor-necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) family with pro-apoptotic activity. The accumulation of apoptotic cell debris has been hypothesized to induce the autoimmune inflammation in SLE, and TRAIL may trigger this programmed cell death. We investigated TRAIL mRNA expression levels in peripheral blood mononuclear cells (PBMCs) from 60 SLE patients and 40 controls using quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR), and we studied the association between the results and clinical and laboratory parameters of the patients. Expression levels of TRAIL mRNAs in SLE patients were significantly higher than in controls (p<0.001). A statistically significant association was detected between TRAIL mRNA expression and SLE activity (p=0.001).
(Copyright © 2013 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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