Oral desmopressin lyophilisate (MELT) for monosymptomatic enuresis: structured versus abrupt withdrawal.

Autor: Ferrara P; Institute of Pediatrics, 'A. Gemelli' University Hospital, Rome, Italy. Electronic address: pferrara@rm.unicatt.it., Romano V; Institute of Pediatrics, 'A. Gemelli' University Hospital, Rome, Italy., Cortina I; Campus Bio-Medico University, Rome, Italy., Ianniello F; Institute of Pediatrics, 'A. Gemelli' University Hospital, Rome, Italy., Fabrizio GC; Institute of Pediatrics, 'A. Gemelli' University Hospital, Rome, Italy., Chiaretti A; Institute of Pediatrics, 'A. Gemelli' University Hospital, Rome, Italy.
Jazyk: angličtina
Zdroj: Journal of pediatric urology [J Pediatr Urol] 2014 Feb; Vol. 10 (1), pp. 52-5. Date of Electronic Publication: 2013 Jun 19.
DOI: 10.1016/j.jpurol.2013.05.021
Abstrakt: Objective: To investigate whether a structured withdrawal program from a sublingual formulation of fast-melting oral desmopressin lyophilisate (MELT) is superior to a sudden withdrawal from this formulation in the treatment of monosymptomatic nocturnal enuresis.
Materials and Methods: One hundred and three children presented to our pediatric nephrology outpatient clinic for bedwetting. Eighty-one children, aged between 5½ and 14 years (mean age 8.64 years), were treated with MELT at a dosage of 120 mcg a day. Responders were randomized to been withdrawn from therapy, after 3 months, abruptly or in a structured withdrawal program (60 mcg/day for 15 days and then 60 mcg every second evening for another 15 days). Main outcome parameter was relapse rate 1 month after the end of treatment. Relapse was defined as bedwetting occurring more than 2 nights per month after the 1-month treatment-free period.
Results: Relapse rate at 1 month after the end of treatment was 47.83% in the group on a structured program versus 45.83% in the abrupt termination group (p = 0.89).
Conclusion: Our study suggests that a structured withdrawal program from MELT therapy doesn't offer advantages compared to an abrupt termination in children with monosymptomatic nocturnal enuresis.
(Copyright © 2013 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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