Phenolic-rich extract from the Costa Rican guava (Psidium friedrichsthalianum) pulp with antioxidant and anti-inflammatory activity. Potential for COPD therapy.

Autor: Flores G; Department of Biological Sciences, Lehman College and the Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, USA., Dastmalchi K, Wu SB, Whalen K, Dabo AJ, Reynertson KA, Foronjy RF, D Armiento JM, Kennelly EJ
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2013 Nov 15; Vol. 141 (2), pp. 889-95. Date of Electronic Publication: 2013 Mar 16.
DOI: 10.1016/j.foodchem.2013.03.025
Abstrakt: The potential therapeutic effects of Costa Rican guava (Psidium friedrichsthalianum) extracts for chronic obstructive pulmonary disease were examined. The ethyl acetate fraction displayed the highest antioxidant activity, as compared to the hexane, chloroform, and n-butanol fractions, as well as the crude extract. This fraction was evaluated for its anti-inflammatory activity response relationship against interleukin-8 (IL-8) and inhibition of matrix metalloproteinase-1 (MMP-1) expression before and after treatment with cigarette smoke. The ethyl acetate fraction exhibited inhibitory activity against IL-8 production and MMP-1 expression, showing the most potent inhibitory activities in both assays at 100μg/mL, and nine compounds (1-9) were found. Phenolic compounds 1-O-trans-cinnamoyl-β-d-glucopyranose (2), ellagic acid (3), myricetin (4), quercitrin (7), and quercetin (9) were identified using standard compounds or literature reports from related species. Compounds 1, 5, 6, and 8 were tentatively identified as 1,5-dimethyl citrate (1), sinapic aldehyde 4-O-β-d-glucopyranose (5), 3,3',4-tri-O-methylellagic acid-4'-O-d-glucopyranoside (6), and 1,3-O-diferuloylglycerol (8), All nine compounds are reported for the first time in Costa Rican guava.
(Copyright © 2013 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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