Stability of three commonly compounded extemporaneous enrofloxacin suspensions for oral administration to exotic animals.
| Autor: | Petritz OA; Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA., Guzman DS, Wiebe VJ, Papich MG |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the American Veterinary Medical Association [J Am Vet Med Assoc] 2013 Jul 01; Vol. 243 (1), pp. 85-90. |
| DOI: | 10.2460/javma.243.1.85 |
| Abstrakt: | Objective: To evaluate the stability of 3 extemporaneous oral suspensions of enrofloxacin mixed with readily available flavoring vehicles when stored at room temperature (approx 22°C). Design: Evaluation study. Samples: 3 commonly compounded oral suspensions of enrofloxacin. Procedures: On day 0, commercially available enrofloxacin tablets were compounded with a mixture of distilled water and corn syrup (formulation A) or cherry syrup (formulation B) flavoring vehicles to create suspensions with a nominal enrofloxacin concentration of 22.95 mg/mL, and 2.27% enrofloxacin injectable solution was compounded with a liquid sweetener (formulation C) to create a suspension with a nominal enrofloxacin concentration of 11.35 mg/mL. Preparations were stored in amber-colored vials at room temperature for 56 days. For each preparation, the enrofloxacin concentration was evaluated with high-performance liquid chromatography at prespecified intervals during the study. The pH, odor, and consistency for all suspensions were recorded at the start and completion of the study. Results: Relative to the nominal enrofloxacin concentration, the enrofloxacin concentration strength ranged from 95.80% to 100.69% for formulation A, 108.44% to 111.06% for formulation B, and 100.99% to 103.28% for formulation C. A mild pH increase was detected in all 3 suspensions during the study. Conclusions and Clinical Relevance: Results indicated that, when stored in amber-colored vials at room temperature for 56 days, the enrofloxacin concentration strength in all 3 formulations was retained within acceptance criteria of 90% to 110%. Subjectively, cherry syrup flavoring was better at masking the smell and taste of enrofloxacin than were the other mixing vehicles. |
| Databáze: | MEDLINE |
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