| Autor: |
Dzagurova TK, Solopova ON, Sveshnikov PG, Korotina NA, Balovneva MV, Leonovich OA, Varlamov NE, Malkin GA, Sotskova SE, Tkachenko EA |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy virusologii [Vopr Virusol] 2013 Jan-Feb; Vol. 58 (1), pp. 40-4. |
| Abstrakt: |
The monoclonal antibodies to Puumala, Dobrava, Hantaan, and Seoul hantaviruses were obtained using mice. The viruses were known to cause HFRS, and two variants of ELISA were designed. First, Hanta-PUU variant, was constructed using monoclonal antibodies to Puumala virus envelope glycoprotein (G(N):G(C)) for detecting only Puumala virus antigen. The second, Hanta-N variant, was constructed using monoclonal antibodies to Dobrava and Puumala nucleocapsid proteins for detecting four above mentioned hantaviruses. Both Hanta-PUU and Hanta-N assays were reliable in detecting specific hantavirus antigens and the immunogenecity of hantavirus vaccines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
