Gender dimorphism in regulation of plasma proteins in streptozotocin-induced diabetic rats.

Autor: Choi JW; Department of Biotechnology, Daegu University, Kyungsan, Republic of Korea., Aseer KR, Chaudhari HN, Mukherjee R, Choi M, Yun JW
Jazyk: angličtina
Zdroj: Proteomics [Proteomics] 2013 Aug; Vol. 13 (16), pp. 2482-94. Date of Electronic Publication: 2013 Jul 23.
DOI: 10.1002/pmic.201200529
Abstrakt: In the present study, we examined differentially regulated plasma proteins between healthy control and streptozotocin (STZ)-induced male and female diabetic rats by 2DE-based proteomic analysis. Animal experiments revealed that significantly lower plasma insulin levels were observed in female diabetic rats, consequently resulting in higher blood glucose levels in female diabetic rats. Importantly, plasma levels of sex hormones were significantly altered in a gender-dependent manner before and after STZ treatment. Results of the animal experiment indicated the existence of sexual dimorphism in the regulation of plasma proteins between healthy control and diabetic rats. Plasma proteome analysis enabled us to identify a total of 38 proteins showing sexual dimorphic regulation patterns. In addition, for the first time, we identified several differentially regulated plasma proteins between healthy control and diabetic rats, including apolipoprotein E, fetuin B, α-1-acid glycoprotein, β-2-glycoprotein 1, 3-hydroxyanthranilate 3,4-dioxygenase, and serum amyloid P-component. To the best of our knowledge, this is the first proteomic approach to address sexual dimorphism in diabetic animals. These proteomic data on gender-dimorphic regulation of plasma proteins provide valuable information that can be used for evidence-based gender-specific clinical treatment of diabetes.
(© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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