Interleukin-6 promoter polymorphisms -174 G/C in Brazilian patients with systemic lupus erythematosus.

Autor: Asano NM; Department of Clinical Medicine, Faculty of Medicine, Universidade Federal de Pernambuco (UFPE), Brazil., Angelo HD, da Silva HA, Maia MM, Lins OG, Souza PE
Jazyk: angličtina
Zdroj: Human immunology [Hum Immunol] 2013 Sep; Vol. 74 (9), pp. 1153-6. Date of Electronic Publication: 2013 Jun 12.
DOI: 10.1016/j.humimm.2013.05.015
Abstrakt: To investigate the association of the IL-6 gene promoter polymorphism (-174 G/C) with SLE susceptibility and disease features in Brazilian patients, a case-control study of 80 lupus cases and 60 volunteer healthy women was performed. Genotyping was carried out by polymerase chain reaction and PCR product was digested by HSP92II restriction enzyme, being after visualized in polyacrylamide gel. There were significant differences in the distribution of the IL-6 gene C/C polymorphism between the SLE and control groups (χ(2) = 8.668; P = 0.0032). Individual carriers of the variant allele G had a 1.98 (95% CI: 1.0844-3.6353)-fold increased risk for SLE. Besides, association was observed in frequency of C allele (P = 0.0247; OR = 0.5036) between SLE patients and control groups. This study presents preliminary evidence for association between IL-6 polymorphism and SLE susceptibility in a Northeast population from Brazil.
(Copyright © 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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