Highly diversified coronaviruses in neotropical bats.

Autor: Corman VM; Institute of Virology, University of Bonn Medical Centre, Bonn, Germany., Rasche A; University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.; Institute of Virology, University of Bonn Medical Centre, Bonn, Germany., Diallo TD; Institute of Virology, University of Bonn Medical Centre, Bonn, Germany., Cottontail VM; Institute of Experimental Ecology, University of Ulm, Ulm, Germany., Stöcker A; Infectious Diseases Research Laboratory, University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Brazil., Souza BFCD; Infectious Diseases Research Laboratory, University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Brazil., Corrêa JI; Infectious Diseases Research Laboratory, University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Brazil., Carneiro AJB; School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil., Franke CR; School of Veterinary Medicine, Federal University of Bahia, Salvador, Brazil., Nagy M; Museum für Naturkunde, Leibniz Institute for Research on Evolution and Biodiversity, Berlin, Germany., Metz M; Fondazione Edmund Mach, Research and Innovation Centre, Department of Biodiversity and Molecular Ecology, S. Michele all'Adige, Italy., Knörnschild M; Institute of Experimental Ecology, University of Ulm, Ulm, Germany., Kalko EKV; Smithsonian Tropical Research Institute, Balboa, Panama.; Institute of Experimental Ecology, University of Ulm, Ulm, Germany., Ghanem SJ; Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany., Morales KDS; Instituto Internacional en Conservación y Manejo de Vida Silvestre, Universidad Nacional, Heredia, Costa Rica., Salsamendi E; Department of Zoology and Animal Cell Biology, University of the Basque Country, Bilbao, The Basque Country.; Institute of Experimental Ecology, University of Ulm, Ulm, Germany., Spínola M; Instituto Internacional en Conservación y Manejo de Vida Silvestre, Universidad Nacional, Heredia, Costa Rica., Herrler G; University of Veterinary Medicine Hannover, Foundation, Hannover, Germany., Voigt CC; Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany., Tschapka M; Smithsonian Tropical Research Institute, Balboa, Panama.; Institute of Experimental Ecology, University of Ulm, Ulm, Germany., Drosten C; Institute of Virology, University of Bonn Medical Centre, Bonn, Germany., Drexler JF; Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Jazyk: angličtina
Zdroj: The Journal of general virology [J Gen Virol] 2013 Sep; Vol. 94 (Pt 9), pp. 1984-1994. Date of Electronic Publication: 2013 Jun 12.
DOI: 10.1099/vir.0.054841-0
Abstrakt: Bats host a broad diversity of coronaviruses (CoVs), including close relatives of human pathogens. There is only limited data on neotropical bat CoVs. We analysed faecal, blood and intestine specimens from 1562 bats sampled in Costa Rica, Panama, Ecuador and Brazil for CoVs by broad-range PCR. CoV RNA was detected in 50 bats representing nine different species, both frugivorous and insectivorous. These bat CoVs were unrelated to known human or animal pathogens, indicating an absence of recent zoonotic spill-over events. Based on RNA-dependent RNA polymerase (RdRp)-based grouping units (RGUs) as a surrogate for CoV species identification, the 50 viruses represented five different alphacoronavirus RGUs and two betacoronavirus RGUs. Closely related alphacoronaviruses were detected in Carollia perspicillata and C. brevicauda across a geographical distance exceeding 5600 km. Our study expands the knowledge on CoV diversity in neotropical bats and emphasizes the association of distinct CoVs and bat host genera.
Databáze: MEDLINE