Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection.

Autor: Farías AA; Facultad de Ciencias Médicas, Instituto de Virología Dr J M Vanella, Universidad Nacional de Córdoba, Córdoba, Argentina. adrianalefarias@hotmail.com, Kremer LE, Allende L, Díaz Mdel P, Pisano MB, Contigiani MS, Ré VE
Jazyk: angličtina
Zdroj: Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2013 Jul; Vol. 107 (7), pp. 432-7. Date of Electronic Publication: 2013 Jun 11.
DOI: 10.1093/trstmh/trt043
Abstrakt: Background: The purpose of this study was to update the epidemiological data on the prevalence of coinfection with hepatitis C virus (HCV) and HIV, and to identify whether specific clinical and epidemiological factors influenced the response of HIV-positive adults to highly active antiretroviral therapy (HAART).
Methods: This retrospective observational cohort study of 238 HIV-infected patients evaluated the effect of different epidemiological and clinical parameters (including HCV coinfection) on therapy response among HIV-infected adults initiating HAART. Multiple logistic regression models were used to identify factors associated with therapy response and estimated risk coefficients.
Results: Seroprevalence of HCV infection in this population was 26% (62/238). We did not observe a significant association between immunological or virological response relating to patient gender or HAART regimen. However, this analysis showed that HCV serological status, age at HIV diagnosis, duration of treatment and WHO clinical stage of AIDS (<200 CD4 cells/ml independently of viral load either < or > to 100,000 copies/ml), were significantly associated with immunological and virological responses to HAART.
Conclusions: These results show further evidence that hepatitis C serostatus is associated with a reduced response to HAART.
Databáze: MEDLINE
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