| Abstrakt: |
Many of well-known genes-suppressors, beside protecting tissues against unlimited cells division and forming neoplastic tumors, cause various effects on animals development, vital functions, and fitness. Pleiotropic effects of these genes are due to their primary functions related with controlling of key cell processes. By making up complex compounds with other proteins, the products of genes-suppressors form cell contacts and polarity; take part in transmission of molecular signals that govern vitally important processes in a developing organism; control the cell cycle, growth, and proliferation; modulate signal paths of cell survival and preprogrammed death that protect an organism against defective structures in critical situations. Despite of tumor suppressors' vital importance, their lethal mutations are widespread in animal populations, while ensuring higher fitness under natural conditions when being in a heterozygous state. |
