| Autor: |
Bošnjak I; Laboratory for Biology and Microbial Genetics, Department of Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000, Zagreb, Croatia, ibosnjak@pbf.hr., Zaja R, Klobučar RS, Šver L, Franekić J, Smital T |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of environmental contamination and toxicology [Bull Environ Contam Toxicol] 2013 Oct; Vol. 91 (4), pp. 415-9. Date of Electronic Publication: 2013 Jun 07. |
| DOI: |
10.1007/s00128-013-1021-8 |
| Abstrakt: |
Multixenobiotic resistance (MXR) represents an important cellular detoxification mechanism in aquatic organisms as it provides them robustness toward natural and man-made contaminants. Several ABC transporters have major roles in the MXR phenotype - P-gp/ABCB1, MRP1-3/ABCC1-3 and BCRP/ABCG2. In this study, we identified the presence of ABC transporters involved in the MXR mechanism of Arbacia lixula and Paracentrotus lividus. AlABCB1/P-gp, AlABCC3/MRP3, AlABCC9/SUR-like and AlABCG-like transcripts were identified in A. lixula; and PlABCC1/P-gp, PlABCC3/MRP3, PlABCC5/MRP5, and PlABCC9/SUR-like transcripts in P. lividus. For each of the new partial sequences, we performed detailed phylogenetic and identity analysis as a first step toward full characterization and understanding of the ecotoxicological role of these ABC transporters. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink