Critical evaluation of mixed treatment comparison meta-analyses using examples assessing antidepressants and opioid detoxification treatments.

Autor: Schacht A; Eli Lilly, Global Statistical Sciences, Bad Homburg, Germany. schacht_alexander@lilly.com, Dyachkova Y, Walton RJ
Jazyk: angličtina
Zdroj: International journal of methods in psychiatric research [Int J Methods Psychiatr Res] 2013 Jun; Vol. 22 (2), pp. 166-74. Date of Electronic Publication: 2013 Jun 06.
DOI: 10.1002/mpr.1381
Abstrakt: Comparing multiple treatment options using meta-analytical methods requires complex statistical methods called mixed treatment comparisons (MTCs). Such methods offer the possibility to summarize data from many clinical trials comparing the different available options. However, those methods are based on a number of assumptions and inherent difficulties that are discussed and illustrated with examples from the psychiatric literature to help readers to understand the strengths and weaknesses of these methods. This review will help enable readers to critically appraise the methodology and results of publications that use MTCs.
(Copyright © 2013 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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