| Autor: |
Feijs KL; Institute of Biochemistry and Molecular Biology, Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany., Forst AH, Verheugd P, Lüscher B |
| Jazyk: |
angličtina |
| Zdroj: |
Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2013 Jul; Vol. 14 (7), pp. 443-51. Date of Electronic Publication: 2013 Jun 05. |
| DOI: |
10.1038/nrm3601 |
| Abstrakt: |
ADP-ribosylation of proteins was first described in the early 1960's, and today the function and regulation of poly(ADP-ribosyl)ation (PARylation) is partially understood. By contrast, little is known about intracellular mono(ADP-ribosyl)ation (MARylation) by ADP-ribosyl transferase (ART) enzymes, such as ARTD10. Recent findings indicate that MARylation regulates signalling and transcription by modifying key components in these processes. Emerging evidence also suggests that specific macrodomain-containing proteins, including ARTD8, macroD1, macroD2 and C6orf130, which are distinct from those affecting PARylation, interact with MARylation on target proteins to 'read' and 'erase' this modification. Thus, studying macrodomain-containing proteins is key to understanding the function and regulation of MARylation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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