| Autor: |
Richards DF; Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, CA 94550, USA., Glosli JN, Draeger EW, Mirin AA, Chan B, Fattebert JL, Krauss WD, Oppelstrup T, Butler CJ, Gunnels JA, Gurev V, Kim C, Magerlein J, Reumann M, Wen HF, Rice JJ |
| Jazyk: |
angličtina |
| Zdroj: |
Computer methods in biomechanics and biomedical engineering [Comput Methods Biomech Biomed Engin] 2013; Vol. 16 (7), pp. 802-5. Date of Electronic Publication: 2013 Jun 04. |
| DOI: |
10.1080/10255842.2013.795556 |
| Abstrakt: |
We have developed the capability to rapidly simulate cardiac electrophysiological phenomena in a human heart discretised at a resolution comparable with the length of a cardiac myocyte. Previous scientific investigation has generally invoked simplified geometries or coarse-resolution hearts, with simulation duration limited to 10s of heartbeats. Using state-of-the-art high-performance computing techniques coupled with one of the most powerful computers available (the 20 PFlop/s IBM BlueGene/Q at Lawrence Livermore National Laboratory), high-resolution simulation of the human heart can now be carried out over 1200 times faster compared with published results in the field. We demonstrate the utility of this capability by simulating, for the first time, the formation of transmural re-entrant waves in a 3D human heart. Such wave patterns are thought to underlie Torsades de Pointes, an arrhythmia that indicates a high risk of sudden cardiac death. Our new simulation capability has the potential to impact a multitude of applications in medicine, pharmaceuticals and implantable devices. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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