Serum lipoprotein-A levels in healthy subjects indicate a lurking cerebro- and cardio-vascular risk in the younger population.

Autor: Oliveira SH; Department of Medicine and Nursing, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil., de Miranda MR, Santos Morais CA, Palotás A, Lima LM
Jazyk: angličtina
Zdroj: Brain research bulletin [Brain Res Bull] 2013 Aug; Vol. 97, pp. 48-52. Date of Electronic Publication: 2013 May 28.
DOI: 10.1016/j.brainresbull.2013.05.012
Abstrakt: Lipoprotein-A (LpA) is an emerging independent risk factor for cerebro- and cardio-vascular diseases (CCVD). Recognizing its function and its normal distribution is of fundamental importance for a better understanding of CCVD patho-physiology. The present study evaluated plasma LpA levels of healthy university students using turbidimetric methods. Medians and inter-quartile differences obtained for male and female participants were 11.3mg/dL (3.1-30.7) and 20.9mg/dL (6.5-42.3), respectively, demonstrating a significant difference (P=0.017) between men and women. A third of students showed plasma concentrations above reference values. Our results indicate that 33% of students possess a hidden independent risk factor for CCVD. Multi-disciplinary evaluation and characterization of young individuals should be recommended in an attempt to take early preventive measures and to eliminate possible modifiable risk factors such as sedentary lifestyle, smoking, hypertension, obesity and atherogenic diet.
(Copyright © 2013 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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