| Autor: |
DeMong DE; Discovery and Preclinical Sciences, Merck Research Laboratories, 2015 Galloping Hill Road, K15-2-A218, Kenilworth, New Jersey 07033, USA. duane.demong@merck.com, Ng I, Miller MW, Stamford AW |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2013 Jun 07; Vol. 15 (11), pp. 2830-3. Date of Electronic Publication: 2013 May 28. |
| DOI: |
10.1021/ol401165e |
| Abstrakt: |
A series of 4-arylimidazolones have been accessed via late-stage, palladium-mediated arylation of acetone- and cyclohexanone-derived 4-chloroimidazolones. The 4-chloroimidazolones were prepared via a novel rearrangement of the corresponding imidazolone N-oxides. This communication serves as an expansion of chemistry originally developed for our glucagon receptor antagonist program. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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