| Autor: |
Uosis-Martin M; Department of Chemistry, University of Bath, Bath, BA2 7AY, United Kingdom., Pantoş GD, Mahon MF, Lewis SE |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2013 Jun 21; Vol. 78 (12), pp. 6253-63. Date of Electronic Publication: 2013 Jun 10. |
| DOI: |
10.1021/jo401014n |
| Abstrakt: |
A synthetic approach to complanadine alkaloids is described which employs a Kondrat'eva reaction to construct the pyridine rings. The viability of this approach is demonstrated by its application to a model substrate accessed from unfunctionalized decalin. The key transformation affords the desired tetracyclic architecture with unprecedented incorporation of substituents on the pyridine ring, implicating the oxazole α-hydroxy group as an active participant in the cycloadduct fragmentation process. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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