Incorporation of poly[(R)-3-hydroxybutyrate] into cationic copolymers based on poly(2-(dimethylamino)ethyl methacrylate) to improve gene delivery.

Autor: Loh XJ; Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602, Singapore., Ong SJ, Tung YT, Choo HT
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2013 Aug; Vol. 13 (8), pp. 1092-9. Date of Electronic Publication: 2013 May 22.
DOI: 10.1002/mabi.201300050
Abstrakt: The synthesis and gene transfection efficiency of a series of novel amphiphilic triblock copolymers with two hydrophilic poly(2-(dimethylamino)ethyl methacrylate) (DMAEMA) blocks flanking a central hydrophobic poly[(R)-3-hydroxybutyrate] (PHB) block is reported. These copolymers have significantly lower toxicity compared to the polyethyleneimine (PEI) and PDMAEMA homopolymer. Unexpectedly, the incorporation of PHB significantly improves the gene transfection efficiency as compared to PEI or PDMAEMA homopolymers.
(© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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