Exact results for amplitude spectra of fitness landscapes.
| Autor: | Neidhart J; Institute of Theoretical Physics, University of Cologne, Zülpicher Strasse 77, 50937 Cologne, Germany., Szendro IG, Krug J |
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| Jazyk: | angličtina |
| Zdroj: | Journal of theoretical biology [J Theor Biol] 2013 Sep 07; Vol. 332, pp. 218-27. Date of Electronic Publication: 2013 May 14. |
| DOI: | 10.1016/j.jtbi.2013.05.002 |
| Abstrakt: | Starting from fitness correlation functions, we calculate exact expressions for the amplitude spectra of fitness landscapes as defined by Stadler [1996. Landscapes and their correlation functions. J. Math. Chem. 20, 1] for common landscape models, including Kauffman's NK-model, rough Mount Fuji landscapes and general linear superpositions of such landscapes. We further show that correlations decaying exponentially with the Hamming distance yield exponentially decaying spectra similar to those reported recently for a model of molecular signal transduction. Finally, we compare our results for the model systems to the spectra of various experimentally measured fitness landscapes. We claim that our analytical results should be helpful when trying to interpret empirical data and guide the search for improved fitness landscape models. (Copyright © 2013 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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