Volumetric modulated arc radiotherapy for limited osteosclerotic myeloma.
| Autor: | Robles A; Aurélie Robles, Coralie Moncharmont, Lamine Farid, Jean-Baptiste Guy, Nadia Malkoun, Lysian Cartier, Jean-Noël Talabard, Guy de Laroche, Nicolas Magné, Department of Radiotherapy, Institut de Cancérologie de la Loire, 42270 St Priest en Jarez, France., Levy A, Moncharmont C, Farid L, Guy JB, Malkoun N, Cartier L, Chargari C, Guichard I, Talabard JN, de Laroche G, Magné N |
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| Jazyk: | angličtina |
| Zdroj: | World journal of radiology [World J Radiol] 2013 Apr 28; Vol. 5 (4), pp. 173-7. |
| DOI: | 10.4329/wjr.v5.i4.173 |
| Abstrakt: | Aim: To assess the feasibility of volumetric intensity-modulated arc radiotherapy (VMAT) in patients with limited polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome. Methods: A 70-year-old male with histologically confirmed osteosclerotic myeloma was treated in our department in July 2010 with VMAT. Fourty-six Gray in 23 fractions were given on three bone lesions. Doses delivered to target volume and critical organs were compared with a tridimensional conformal radiotherapy (3D-RT) plan. Treatment was well tolerated without any side effects. Results: VMAT improved dose homogeneity within the target volume, as compared to 3D-RT (standard deviations: 2.9 Gy and 1.6 Gy for 3D and VMAT, respectively). VMAT resulted in a better sparing of critical organs. Dose delivered to 20% of organ volume (D20) was reduced from 22 Gy (3D-RT) to 15 Gy (VMAT) for small bowel, from 24 Gy (3D-RT) to 17 Gy (VMAT) for bladder and from 47 Gy (3D-RT) to 3 Gy (VMAT) for spinal cord. Volumes of critical organs that received at least 20 Gy (V20) were decreased by the use of VMAT, as compared to 3D-RT (V20 bladder: 10% vs 99%; V20 small bowel: 6% vs 21%). One year after treatment completion, no tumor progression has been reported. Conclusion: VMAT improved dose distribution as compared to 3D-RT for limited osteosclerotic myeloma, with better saving of critical organs. |
| Databáze: | MEDLINE |
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